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Us ACTOPLUS MT should b tmpoaily suspndd any sugical pocdu (xcpt minpocdus not associatd with stictd intak ood and luids) and should not b statd until th patint’s oal intak has sumd and nal unction has bn valuatd as nomal.

Postmakting pots congstiv hat ailu hav bn potd in patints tatd with pioglitazon, both with and without pviously known hat disas and both with and without concomitant insulin administation.

NOT: paticipants should not stat homonal thapy th pupos mting th ligibility citia this potocol Ability tundstand and th willingnss tsign a wittn inomd consnt documnt.

Patints civing ACTOPLUS MT in combination with insulin oth antidiabtic mdications (paticulaly insulin sctagogus such as sulonyluas) may b at isk hypoglycmia. A duction in th dos th concomitant antidiabtic mdication may b ncssay tduc th isk hypoglycmia [s DOSAG AND ADMINISTATION ]. Hypoglycmia can alsoccu whn caloic intak is dicint whn stnuous xcis is not compnsatd by caloic supplmnt. ldly, dbilitatd, malnouishd patints, and thos with adnal pituitay insuicincy alcohol intoxication a paticulaly suscptibl thypoglycmic cts. Hypoglycmia may b diicult tcogniz in th ldly, and in popl wha taking bta-adngic blocking dugs.

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actoplus met is the brand name of a combination of the diabetes medications pioglitazone and metformin; it is also available as actoplus met xr, but the formulation is somewhat different and one should not be substituted for the other without a doctor s permission.

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